{"product_id":"p-tiox-serum-cream","title":"P-TIOX Serum + Cream","description":"\u003cp\u003e\u003cb style=\"font-size: 0.875rem;\"\u003e\u003cu\u003eIntro offer\u003c\/u\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv dir=\"auto\"\u003e\n\u003cp dir=\"auto\"\u003ePurchase P-TIOX Moisturiser and P-TIOX Serum together and receive 20% off.\u003c\/p\u003e\n\u003cp\u003eNormally €316\u003cbr\u003eSave €63.20\u003cbr\u003eNow €252.80\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003eP-TIOX Cream by Skinceuticals \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe key actives are:\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003eNiacinamide\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— 5% complex. Supports barrier repair, reduces redness, refines pores, helps pigmentation and improves skin texture.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e10% Myrixin\u003cspan class=\"theme-emoji\"\u003e™\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003ecomplex\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— a plant extract complex concentrated in\u003cspan\u003e \u003c\/span\u003e\u003cb\u003emyricetin\u003c\/b\u003e, a flavonoid. SkinCeuticals positions this as helping reduce the appearance of deep wrinkles and contraction lines.  \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2% Tripeptide complex\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— designed to soften the look of contraction lines caused by repeated facial movement.  \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e1% Crystalide Micropeptide\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— a radiance peptide aimed at improving clarity, luminosity and glass skin transparency.  \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eZinc PCA\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— helps regulate excess oil, supports clearer pores and is useful for combination\/oily skin.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCapryloyl Salicylic Acid \/ LHA\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— a very gentle lipophilic exfoliating acid. Helps refine texture, smooth pores and improve radiance without being as aggressive as traditional salicylic acid.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAdenosine\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— supports collagen signalling, anti-inflammatory repair and softening of fine lines.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCeramide NP + Hydrogenated Lecithin + Shea Butter + Macadamia Oil\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— this is where the cream differs from the serum. It has barrier-supporting lipids, making it more moisturising and cushioning.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003eDipeptide Diaminobutyroyl Benzylamide Diacetate\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— the Syn-Ake style expression-line peptide. It helps soften the appearance of dynamic lines, but it is not Botox.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePalmitoyl Tetrapeptide-10\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— a peptide used for firmness, repair signalling and skin quality.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp dir=\"auto\"\u003eThe  original SkinCeuticals\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eP-TIOX Serum\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eis actually quite impressive from a formulation science perspective. It isn’t simply a Botox in a bottle product—it combines neuromodulating peptides with ingredients that improve barrier function, texture, radiance and mild exfoliation.  \u003c\/p\u003e\n\u003cp\u003eHere’s a breakdown of the science behind each of the key ingredients.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e1. Niacinamide (Vitamin B3)\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— Second ingredient (high concentration)\u003c\/p\u003e\n\u003cp\u003eThis is one of the workhorses of the formula.\u003c\/p\u003e\n\u003cp\u003eScience:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases ceramide production, strengthening the skin barrier.\u003c\/li\u003e\n\u003cli\u003eReduces transepidermal water loss (TEWL).\u003c\/li\u003e\n\u003cli\u003eDecreases inflammation by reducing cytokine activity.\u003c\/li\u003e\n\u003cli\u003eHelps regulate excess sebum.\u003c\/li\u003e\n\u003cli\u003eInhibits transfer of melanosomes, helping reduce pigmentation.\u003c\/li\u003e\n\u003cli\u003eStimulates collagen synthesis over time.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eClinical benefits:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImproves fine lines.\u003c\/li\u003e\n\u003cli\u003eBrightens uneven skin tone.\u003c\/li\u003e\n\u003cli\u003eReduces redness.\u003c\/li\u003e\n\u003cli\u003eRefines pores.\u003c\/li\u003e\n\u003cli\u003eExcellent for rosacea-prone skin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eEvidence:\u003cbr\u003eMost studies demonstrate excellent efficacy at approximately 4–5%.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e2. Gluconolactone (Polyhydroxy Acid - PHA)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA very elegant exfoliating acid.\u003c\/p\u003e\n\u003cp\u003eUnlike glycolic acid:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLarger molecular size.\u003c\/li\u003e\n\u003cli\u003ePenetrates more slowly.\u003c\/li\u003e\n\u003cli\u003eLess irritation.\u003c\/li\u003e\n\u003cli\u003eExcellent for sensitive skin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBenefits:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRemoves dead skin cells.\u003c\/li\u003e\n\u003cli\u003eImproves luminosity.\u003c\/li\u003e\n\u003cli\u003eIncreases epidermal hydration.\u003c\/li\u003e\n\u003cli\u003eSupports barrier repair.\u003c\/li\u003e\n\u003cli\u003eAntioxidant properties.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUnlike AHAs it has minimal photosensitising effects.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e3. Glycerin + Pentylene Glycol + Methyl Gluceth-20\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThese create the hydration system.\u003c\/p\u003e\n\u003cp\u003eTogether they:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAttract water into the epidermis.\u003c\/li\u003e\n\u003cli\u003eImprove skin elasticity.\u003c\/li\u003e\n\u003cli\u003eReduce dehydration lines.\u003c\/li\u003e\n\u003cli\u003eIncrease softness.\u003c\/li\u003e\n\u003cli\u003eEnhance penetration of active ingredients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHydration itself temporarily softens the appearance of fine lines.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e4. Salicylic Acid (BHA)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003ePresent at a relatively low level.\u003c\/p\u003e\n\u003cp\u003eFunctions:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDissolves sebum.\u003c\/li\u003e\n\u003cli\u003eClears pores.\u003c\/li\u003e\n\u003cli\u003eMild anti-inflammatory.\u003c\/li\u003e\n\u003cli\u003eSmooths skin texture.\u003c\/li\u003e\n\u003cli\u003eHelps improve acne-prone skin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe concentration appears designed more for refining texture than for treating acne aggressively.  \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e5. Adenosine\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eOne of the most underrated anti-ageing ingredients.\u003c\/p\u003e\n\u003cp\u003eScience shows it:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImproves dermal collagen production.\u003c\/li\u003e\n\u003cli\u003eStimulates fibroblast activity.\u003c\/li\u003e\n\u003cli\u003eHas anti-inflammatory effects.\u003c\/li\u003e\n\u003cli\u003eSupports wound healing.\u003c\/li\u003e\n\u003cli\u003eImproves elasticity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSeveral clinical studies have demonstrated reductions in wrinkle depth after regular use.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e6. Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn\u003cspan class=\"theme-emoji\"\u003e®\u003c\/span\u003e-Ake)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eOften referred to as a “snake venom peptide.”\u003c\/p\u003e\n\u003cp\u003eMechanism:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eInspired by a peptide found in Temple Viper venom.\u003c\/li\u003e\n\u003cli\u003eWorks by reducing muscle contraction signalling.\u003c\/li\u003e\n\u003cli\u003eRelaxes superficial facial micro-contractions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTargets:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eForehead lines.\u003c\/li\u003e\n\u003cli\u003eCrow’s feet.\u003c\/li\u003e\n\u003cli\u003eFrown lines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIt does\u003cspan\u003e \u003c\/span\u003e\u003cb\u003enot\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eparalyse muscles like botulinum toxin, but may modestly soften dynamic expression lines with consistent use.  \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e7. Acetyl Hexapeptide-8 (Argireline\u003cspan class=\"theme-emoji\"\u003e®\u003c\/span\u003e)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eProbably the most recognised cosmetic neuropeptide.\u003c\/p\u003e\n\u003cp\u003eMechanism:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces release of neurotransmitters involved in muscle contraction.\u003c\/li\u003e\n\u003cli\u003eDecreases repetitive facial movement.\u003c\/li\u003e\n\u003cli\u003eSoftens expression lines over time.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBest evidence:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCrow’s feet.\u003c\/li\u003e\n\u003cli\u003eHorizontal forehead lines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe effect is subtle compared with injectable anti-wrinkle treatments, but it complements them well.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e8. Laminaria Digitata Extract\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBrown seaweed extract.\u003c\/p\u003e\n\u003cp\u003eBenefits:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRich in polysaccharides.\u003c\/li\u003e\n\u003cli\u003eAntioxidant protection.\u003c\/li\u003e\n\u003cli\u003eSoothing.\u003c\/li\u003e\n\u003cli\u003eMineral support.\u003c\/li\u003e\n\u003cli\u003eHelps reduce oxidative stress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMarine extracts also contribute to skin hydration.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003e9. Phytic Acid\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA gentle plant-derived antioxidant.\u003c\/p\u003e\n\u003cp\u003eFunctions:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eChelates iron and copper ions that can promote oxidation.\u003c\/li\u003e\n\u003cli\u003eHelps improve skin brightness.\u003c\/li\u003e\n\u003cli\u003eMild exfoliating effect.\u003c\/li\u003e\n\u003cli\u003eSupports stability of the formula.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 dir=\"auto\"\u003e\u003cb\u003eIngredients that improve the cosmetic feel\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eThese are not “active” ingredients but contribute to the elegant texture:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHydroxyethylcellulose\u003c\/li\u003e\n\u003cli\u003eButylene Glycol\u003c\/li\u003e\n\u003cli\u003ePEG\/PPG\/Polybutylene Glycol\u003c\/li\u003e\n\u003cli\u003ePotassium Hydroxide (pH adjustment)\u003c\/li\u003e\n\u003cli\u003eSodium Benzoate\u003c\/li\u003e\n\u003cli\u003eChlorphenesin (preservative)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 dir=\"auto\"\u003e\u003cb\u003eThe one ingredient: to be aware of on a very sensitive skin -  Alcohol Denat.\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003ePotential advantages:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCreates a lightweight, fast-absorbing finish.\u003c\/li\u003e\n\u003cli\u003eEnhances penetration of peptides.\u003c\/li\u003e\n\u003cli\u003eReduces tackiness.\u003c\/li\u003e\n\u003cli\u003eImproves cosmetic elegance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePotential disadvantages:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCan be drying for very dry or compromised skin.\u003c\/li\u003e\n\u003cli\u003eMay increase irritation in highly sensitive skin if not balanced by humectants.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eIn this formula, the alcohol is offset by substantial amounts of glycerin, niacinamide and multiple humectants, making it less concerning for most skin types.\u003c\/b\u003e\u003c\/p\u003e\n\u003ch2 dir=\"auto\"\u003e\u003cspan\u003eOverall assessment: \u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eFrom a formulation standpoint, P-TIOX Serum is designed around four complementary mechanisms:\u003c\/p\u003e\n\u003col start=\"1\"\u003e\n\u003cli\u003e\n\u003cb\u003eExpression-line modulation:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eSyn\u003cspan class=\"theme-emoji\"\u003e®\u003c\/span\u003e-Ake + Argireline + adenosine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eBarrier repair and hydration:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eNiacinamide, glycerin and multiple humectants.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTexture refinement:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eGluconolactone and salicylic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eRadiance and skin quality:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eNiacinamide, gentle exfoliation and antioxidant support.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp dir=\"auto\"\u003eUnlike many peptide serums that rely almost entirely on marketing claims, this formulation combines peptides with ingredients that have strong evidence for improving overall skin health. It is best viewed as a comprehensive anti-ageing serum rather than simply a Botox alternative.For many patients, it pairs particularly well with injectable anti-wrinkle treatments, helping maintain smoother skin while also addressing texture, hydration and luminosity—benefits that botulinum toxin alone cannot provide.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003eP-TIOX Cream is a wrinkle-modulating, pore-refining moisturiser\u003c\/b\u003e\u003cspan\u003e, while \u003c\/span\u003e\u003cb\u003eP-TIOX Serum is more of a concentrated smoothing serum\u003c\/b\u003e\u003cspan\u003e. The cream is more supportive for barrier, hydration and texture, especially when clients want glow, smoother pores and a softer look around expression lines.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cspan\u003eSkinCeuticals \u003c\/span\u003e\u003cb\u003eP-TIOX Cream\u003c\/b\u003e\u003cspan\u003e is a corrective anti-wrinkle moisturiser designed to soften the appearance of expression lines, deep wrinkles, pores and uneven texture.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e \u003c\/p\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp dir=\"auto\"\u003eIt combines\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e10% Myrixin \u003c\/b\u003e \u003cb\u003e2% Tripeptide\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e1% Crystalide -  micropeptide\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e5% Niacinamide\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eZinc PCA\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eLHA\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003eIn simple terms:\u003cbr\u003eit helps skin look\u003cspan\u003e \u003c\/span\u003e\u003cb\u003esmoother, brighter, more refined and more relaxed\u003c\/b\u003e, while also supporting the barrier and controlling excess oil.\u003c\/p\u003e\n\u003cp\u003eBest positioned as:\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cb\u003eA daily corrective moisturiser for clients concerned with expression lines, visible wrinkles, uneven texture, pores and loss of radiance.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eIt is not a replacement for anti-wrinkle injections, but it is an excellent topical partner for clients who want smoother skin quality between treatments. And of course it can be used if not having injectables . \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhy the ingredients work together? \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e \u003c\/p\u003e\n\u003cdiv\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"8\" width=\"100%\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003e\n\u003cp\u003e\u003cb\u003eIngredient\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/th\u003e\n\u003cth\u003e\n\u003cp\u003e\u003cb\u003ePrimary target\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/th\u003e\n\u003cth\u003e\n\u003cp\u003e\u003cb\u003eBiological effect\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"auto\"\u003eMyrixin\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eExpression lines\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eHelps reduce visible muscle contraction effects\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eTripeptide\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eFibroblasts\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eStimulates collagen and extracellular matrix production\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"auto\"\u003eCrystalide\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eEpidermis\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eImproves keratinocyte differentiation and skin radiance\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eNiacinamide\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eBarrier and cellular metabolism\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eSupports ceramide synthesis, DNA repair and reduces inflammation\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eLHA\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eSkin surface and pores\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eGentle targeted exfoliation and texture refinement\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003eZinc PCA\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eSebaceous glands\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003eRegulates sebum while supporting hydration\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e \u003c\/p\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp dir=\"auto\"\u003eThe strength of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eP-TIOX Cream\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003elies in the fact that each ingredient targets a different biological pathway involved in skin ageing. Instead of relying on one hero ingredient, it addresses multiple mechanisms simultaneously.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003e\u003cb\u003e10% Myrixin  – Expression line modulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eMyrixin is SkinCeuticals’ proprietary active designed to reduce the appearance of contraction lines.\u003c\/p\u003e\n\u003cp\u003eExpression lines form because facial muscles contract thousands of times each day. Over time, repeated contraction causes collagen and elastin to fatigue, and dynamic lines become permanent static wrinkles.\u003c\/p\u003e\n\u003cp\u003eMyrixin is designed to influence the communication between nerve endings and muscle cells at the skin level, helping to reduce the visible effects of repeated muscle contraction without paralysing the muscle as botulinum toxin does.\u003c\/p\u003e\n\u003cp\u003ePotential biological effects include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReducing visible muscle contraction-related wrinkling\u003c\/li\u003e\n\u003cli\u003eDecreasing mechanical stress placed on collagen fibres\u003c\/li\u003e\n\u003cli\u003eHelping prevent dynamic wrinkles progressing to static wrinkles\u003c\/li\u003e\n\u003cli\u003eImproving skin smoothness over time\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"auto\"\u003e\u003cb\u003e2% Tripeptide – Cellular signalling and collagen renewal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003ePeptides are short chains of amino acids that act as biological messengers.\u003c\/p\u003e\n\u003cp\u003eAs collagen breaks down with age, natural peptide signalling decreases. Applying specific peptides can “remind” fibroblasts to resume repair processes.\u003c\/p\u003e\n\u003cp\u003eTripeptides help stimulate fibroblasts to produce:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCollagen I\u003c\/li\u003e\n\u003cli\u003eCollagen III\u003c\/li\u003e\n\u003cli\u003eElastin\u003c\/li\u003e\n\u003cli\u003eExtracellular matrix proteins\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis contributes to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImproved firmness\u003c\/li\u003e\n\u003cli\u003eBetter elasticity\u003c\/li\u003e\n\u003cli\u003eIncreased dermal density\u003c\/li\u003e\n\u003cli\u003eReduced wrinkle depth\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"auto\"\u003e\u003cb\u003e1% Crystalide  Micropeptide – Epidermal renewal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eCrystalide works differently from collagen stimulators.\u003c\/p\u003e\n\u003cp\u003eRather than focusing on the dermis, it encourages healthier epidermal differentiation.\u003c\/p\u003e\n\u003cp\u003eHealthy skin renews approximately every 28 days in youth. With ageing, turnover slows, leading to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDullness\u003c\/li\u003e\n\u003cli\u003eRough texture\u003c\/li\u003e\n\u003cli\u003eUneven light reflection\u003c\/li\u003e\n\u003cli\u003eLoss of radiance\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCrystalide helps optimise keratinocyte maturation, improving:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSurface smoothness\u003c\/li\u003e\n\u003cli\u003eOptical clarity\u003c\/li\u003e\n\u003cli\u003eLight reflectance\u003c\/li\u003e\n\u003cli\u003eSkin transparency\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003eThis explains the  glass skin  appearance often associated with this ingredient.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003e\u003cb\u003e5% Niacinamide – The multitasking vitamin\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNiacinamide (Vitamin B3) is one of the most extensively researched skincare ingredients.\u003c\/p\u003e\n\u003cp\u003eIt functions as a precursor to NAD⁺ (nicotinamide adenine dinucleotide), a coenzyme essential for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCellular energy production\u003c\/li\u003e\n\u003cli\u003eDNA repair\u003c\/li\u003e\n\u003cli\u003eHealthy mitochondrial function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWithin skin it has numerous effects:\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBarrier repair\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIncreases ceramide synthesis\u003c\/li\u003e\n\u003cli\u003eImproves cholesterol production\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\nEnhances free fatty acid production\u003c\/li\u003e\n\u003cli\u003eReduces transepidermal water loss (TEWL)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003ePigmentation\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces transfer of melanosomes from melanocytes to keratinocytes\u003c\/li\u003e\n\u003cli\u003eHelps improve uneven skin tone\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eInflammation\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces inflammatory cytokines\u003c\/li\u003e\n\u003cli\u003eCalms redness\u003c\/li\u003e\n\u003cli\u003eSupports sensitive skin\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eAgeing\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImproves fine lines\u003c\/li\u003e\n\u003cli\u003eEnhances elasticity\u003c\/li\u003e\n\u003cli\u003eIncreases dermal resilience\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"auto\"\u003e\u003cb\u003eLHA (Lipo-Hydroxy Acid)  exfoliation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eLHA is a lipid-soluble derivative of salicylic acid.\u003c\/p\u003e\n\u003cp\u003eIts lipophilic nature allows it to concentrate within the oily environment of the pore rather than remaining on the skin surface.\u003c\/p\u003e\n\u003cp\u003eUnlike stronger acids, LHA works slowly and precisely.\u003c\/p\u003e\n\u003cp\u003eBenefits include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBreaking down corneodesmosomes (the structures holding dead skin cells together)\u003c\/li\u003e\n\u003cli\u003eEncouraging gentle desquamation\u003c\/li\u003e\n\u003cli\u003eRefining pores\u003c\/li\u003e\n\u003cli\u003eSmoothing texture\u003c\/li\u003e\n\u003cli\u003eImproving penetration of active ingredients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBecause it exfoliates gradually, it generally causes less irritation than many alpha hydroxy acids.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003e\u003cb\u003eZinc PCA – Sebum regulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eZinc PCA combines zinc with pyrrolidone carboxylic acid (PCA), a component of the skin’s natural moisturising factor.\u003c\/p\u003e\n\u003cp\u003eZinc contributes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAnti-inflammatory activity\u003c\/li\u003e\n\u003cli\u003eRegulation of sebaceous gland activity\u003c\/li\u003e\n\u003cli\u003eReduced bacterial proliferation\u003c\/li\u003e\n\u003cli\u003eAntioxidant support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePCA contributes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eWater binding\u003c\/li\u003e\n\u003cli\u003eImproved hydration\u003c\/li\u003e\n\u003cli\u003eMaintenance of barrier function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTogether they help:\u003c\/p\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003eReduce excess oil\u003c\/li\u003e\n\u003cli\u003eMinimise shine\u003c\/li\u003e\n\u003cli\u003eImprove pore appearance\u003c\/li\u003e\n\u003cli\u003eSupport acne-prone skin without excessive drying\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"SkinCeuticals","offers":[{"title":"Default Title","offer_id":53883421229394,"sku":null,"price":252.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0087\/2241\/5680\/files\/IMG_8378.jpg?v=1782817978","url":"https:\/\/www.nualawoulfe.ie\/products\/p-tiox-serum-cream","provider":"NualaWoulfe","version":"1.0","type":"link"}