What It Is
Polynucleotides are the newest advancement in regenerative aesthetics — a treatment that goes beyond hydration to actively repair, rebuild, and rejuvenate the skin at a cellular level.
They are purified DNA fragments, usually derived from salmon or trout, that mimic the body’s own natural repair molecules. Once injected, they act as biostimulators, encouraging the skin to heal, renew, and function more youthfully.
Why It’s Capturing Attention
It’s fair to say that polynucleotides have taken the industry by storm.
While hyaluronic acid treatments such as Profhilo provide deep hydration, polynucleotides offer something broader — true regeneration.
They help tired, stressed, or ageing skin recover its strength, elasticity, and glow through a natural process rather than by adding volume or artificial structure.
Results are gradual and authentic — skin looks healthier, firmer, and more resilient with every session.
The Science – Regenerative Medicine in Action
Polynucleotides belong to the field of regenerative medicine — therapies designed to restore the body’s own repair mechanisms.
In the skin, they work by:
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Stimulating fibroblasts, the cells responsible for collagen and elastin production.
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Improving microcirculation and oxygen delivery, enhancing skin tone and healing.
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Neutralising free radicals — acting as natural antioxidants that calm inflammation.
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Activating cellular communication, helping damaged tissue repair itself.
Over several weeks, this biochemical “reawakening” strengthens the dermal structure, restores hydration, and improves texture and tone.
How It Works
The treatment involves a series of precise micro-injections into targeted areas such as the face, neck, or under-eye region.
The polynucleotides integrate naturally with skin tissue, stimulating regeneration without adding bulk or altering shape.
Most clients notice visible improvement after two to three sessions, with continued progress over the following months as collagen renewal takes place.
Contraindications
Polynucleotide treatments are not suitable for:
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Pregnancy or breastfeeding
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Active skin infections or inflammation in the treatment area
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Autoimmune disorders or certain chronic illnesses affecting the immune system
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Known fish or seafood allergies (as the material is marine-derived)
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Clients taking anticoagulants or with bleeding disorders
A thorough medical consultation with a qualified practitioner is essential before treatment to ensure safety and suitability.
Polynucleotides vs Profhilo®️️
Both treatments are injectable biostimulators, but they work through different mechanisms.
Profhilo®️️ uses stabilised hyaluronic acid to hydrate and remodel the skin by stimulating collagen and elastin through deep hydration.
Polynucleotides, on the other hand, are cellular repair molecules that trigger tissue regeneration, reduce inflammation, and restore the skin’s natural architecture.
Profhilo excels in improving hydration, smoothness, and elasticity, while polynucleotides are exceptional for healing, firmness, and regeneration — particularly beneficial for stressed, thin, or post-procedure skin.
In many cases, the two treatments complement each other beautifully when used in a structured programme, each enhancing the other’s results.
In Summary
Polynucleotides represent the future of aesthetic medicine — science meeting self-repair.
They don’t mask ageing; they help reverse its effects from within, restoring cellular balance, strength, and radiance.
At Woulfe Skin & Wellness, these regenerative treatments are delivered only by qualified medical professionals with advanced training and access to clinically validated products.
The outcome is skin that looks refreshed, alive, and authentically renewed — your natural beauty, scientifically restored.
