Many clients tell us: 'I want healthier skin without looking like I've had work done.'
Modern regenerative aesthetic medicine focuses on improving skin quality rather than changing facial features. The expertise of your Doctor is essential for positive attractive outcomes.
Depending on your skin concerns, this may include carefully combining:
• Allergan anti-wrinkle injections to relax muscles that create expression lines
• Profhilo to deeply hydrate and stimulate collagen and elastin
• Polynucleotides to support skin repair and regeneration
Each treatment works differently. Together they can create softer lines, healthier skin quality and a fresher appearance while maintaining natural facial movement. Recent systematic reviews suggest polynucleotides show promising improvements in skin texture, elasticity and wrinkle reduction, although larger high-quality studies are still needed to establish the strongest evidence base. Polynucleotides have demonstrated notable efficacy in enhancing skin hydration, elasticity, and overall dermal health, primarily through mechanisms that promote cellular repair and collagen synthesis. This systematic review synthesises findings from various clinical studies to elucidate the significant therapeutic potentials of polynucleotides, revealing their capacity to improve skin texture and integrity, which are critical in the aesthetic rejuvenation of aging skin.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11311621/
https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16721
Profhilo®
Bio-remodelling from within. Profhilo® is one of the most significant developments in injectable skin treatments over the past decade. Unlike traditional dermal fillers, Profhilo is not designed to change the shape of your face or add volume. Instead, it belongs to a newer category of injectable treatments known as bio-remodellers, designed to improve skin quality by supporting the skin's own biological processes.
What makes Profhilo different?
Profhilo contains 64 mg of highly purified hyaluronic acid, one of the highest concentrations available in an injectable treatment.
The science
Hyaluronic acid is naturally present throughout healthy skin.It helps maintain hydration, supports the extracellular matrix and creates the environment in which skin cells function.
As we age:
- Hyaluronic acid levels decline.
- Fibroblasts become less active.
- Collagen and elastin production slows.
- The skin becomes thinner, drier and less elastic.
- Skin laxity gradually develops.
- Profhilo is designed to improve this biological environment.
Laboratory studies suggest that its hybrid hyaluronic acid complexes stimulate fibroblasts, keratinocytes and adipose-derived stem cells, supporting the production of collagen, elastin and healthy extracellular matrix components. This process is known as bio-remodelling.
Supporting multiple collagen types
One of the unique features reported for Profhilo is its ability to support several components of the skin's structural framework.
Research has demonstrated increased expression of:
· Collagen I – providing strength and structural support.
· Collagen III – associated with tissue repair and youthful skin.
· Collagen IV – an important component of the basement membrane.
· Collagen VII – forming anchoring fibrils that help secure the epidermis to the dermis.
It also supports elastin, helping improve the skin's elasticity and resilience.
What can Profhilo improve?
- Profhilo may help improve:
- Skin hydration
- Elasticity
- Firmness
- Skin laxity
- Fine lines
- Crepey skin
- Overall skin quality
- Neck and décolletage ageing
Rather than making you look different, the aim is to help your skin become healthier, stronger and more resilient.
Why is a course recommended?
Skin regeneration takes time. Profhilo is generally recommended as an initial course of two treatments approximately four weeks apart, allowing the bio-remodelling process to develop. Maintenance treatments may then be recommended based on your skin and ageing process.
Is Profhilo a filler?
No. Although it contains hyaluronic acid, Profhilo is not a volumising filler. Its low viscosity allows it to spread through the tissue, improving hydration and supporting skin quality rather than sculpting or changing facial contours. This makes it particularly attractive for clients who want a fresher, healthier appearance while maintaining completely natural facial features.
Why choose Profhilo?
Profhilo may be ideal if your main concerns are:
- Dull, dehydrated skin
- Fine lines
- Crepey texture
- Reduced elasticity
- Early skin laxity
- A desire for subtle, natural-looking rejuvenation
At Woulfe Skin Specialists, every Profhilo treatment begins with a comprehensive consultation with Dr Fiona Curran, who will assess your skin, facial anatomy, medical history and treatment goals before recommending whether Profhilo, polynucleotides or another regenerative treatment is most appropriate for you. Because beautiful results begin with the correct diagnosis—not simply the correct injection.
https://pubmed.ncbi.nlm.nih.gov/41731228/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9509274/
