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Inflammageing Explained: The Hidden Link Between Inflammation, Skin Ageing and Healthy Ageing

Inflammageing Explained: The Hidden Link Between Inflammation, Skin Ageing and Healthy Ageing

Inflammageing Explained: The Hidden Link Between Inflammation, Skin Ageing and Healthy Ageing

Ageing is not caused by one process. It is the result of many biological changes occurring simultaneously,  changes in DNA repair, mitochondria, cellular communication, protein quality control, metabolism, immune function and our ability to repair damage. One increasingly important piece of this puzzle is inflammageing.

First, inflammation is not the enemy

Inflammation is essential. If we injure ourselves or encounter an infection, inflammatory signalling helps mobilise immune cells, remove damaged material and begin repair. The problem is not inflammation itself. It is inflammation that fails to resolve appropriately. Researchers use the term inflammageing to describe the persistent, low-grade inflammatory state that tends to increase with age. It is now closely connected with the recognised biological hallmarks of ageing. 

Where does it come from?

There isn’t one source. Potential contributors include:

  • cellular senescence
  • mitochondrial dysfunction
  • metabolic dysfunction
  • changes in the microbiome
  • accumulated cellular damage
  • visceral adipose tissue
  • environmental exposures
  • persistent immune activation
  • and changes in immune regulation itself.

This creates an important feedback loop. Inflammation can contribute to cellular damage. Damaged and dysfunctional cells can then produce signals that promote further inflammation.

What does this have to do with skin?

Quite a lot. Skin ageing involves interactions between oxidative stress, inflammation, UV exposure, mitochondrial changes, cellular senescence and breakdown of the extracellular matrix. Inflammatory signalling can increase enzymes involved in degradation of structural proteins within the skin. But this doesn’t mean every wrinkle is caused by inflammation. Chronological ageing, hormones, genetics, UV exposure, smoking, pollution, nutrition and many other factors contribute.

Can we simply reduce inflammation?

This phrase is everywhere in wellness. Human biology is not that simple. We need an effective inflammatory response when it is required. The goal isn’t to eliminate inflammation. It is to support healthy immune and metabolic regulation and reduce unnecessary chronic inflammatory stress. Regular movement, adequate sleep, a nutritious diet, avoiding smoking, managing metabolic risk and sensible UV protection all matter.

Our approach to skin

This is why healthy-ageing skincare shouldn’t consist solely of trying to stimulate the skin harder and harder. We also need to protect it.

  • Antioxidants.
  • Photoprotection.
  • Barrier support.
  • Appropriate professional treatments.
  • Recovery between treatments.

SkinCeuticals antioxidant programmes and Heliocare photoprotection can form part of this preventive approach, while treatments such as LED may be selected according to the individual skin. The message from inflammageing science is bigger than skincare. Healthy ageing depends not only on our ability to stimulate change — but also on our ability to regulate, repair and recover.

September 22, 2026