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April 09, 2023 3 min read


Skin glycation, a process that alters our youthful collagen. This process occurs in the presence of higher blood sugars. These higher blood sugars result in changes to the collagen and elastin fibers in the skin, which results in the formation of advanced glycation end products. These are referred to as AGEs. Over time, these changes in the collagen and elastin fibres  manifest as wrinkling and sagging of the skin. 

While controlling your blood sugar is important step in preventing sugar sag, eating more of certain foods can help also. This is because certain foods have actually been shown to help combat the production of AGEs or help reduce the damage caused by AGEs.

In laboratory studies, several herbs and spices have helped to reduce the production of AGES. These have included cinnamon, cloves, oregano, and allspice. Other dietary compounds that have helped to reduce AGE formation include ginger, garlic, and green tea catechins, among others.

Dietary antioxidants may also help limit the tissue damage caused by AGEs, which is yet another reason to eat more foods that are naturally high in antioxidants.

Research has shown that certain antioxidants that are provided via our diet can actually prevent, on a molecular level, some of the damage inflicted by UV radiation. For example, tomato paste given before exposure to UV radiation actually limited the sunburn response. A sunburn is the outward sign of cellular damage, and in one study, subjects who ate about 2 tablespoons of tomato paste daily for 10 weeks showed less of a sunburn response after being exposed to UV radiation. This isn't the same as sunscreen, of course, but it adds an extra level of protection against the damaging effects of the sun's rays.


AGE Advanced by SkinCeuticals is a Breakthrough corrective cream helps reverse visible signs of ageing impacted by glycation and collagen decline, including fine lines and deep wrinkles.

SKIN TYPES: Dry, Normal, Combination, Sensitive


Backed by 15+ years of glycation research and expertise, A.G.E. Interrupter Advanced is a potent anti-wrinkle cream that helps correct and defend against visible signs of ageing. Formulated with 18% concentrated ProxylaneTM, 4.25% wild fruit flavonoid blend of blueberry and pomegranate extracts, and 0.1% glycyrrhetinic acid, this breakthrough corrective cream is clinically proven to smooth visible lines and deep wrinkles in five facial zones targeted for aesthetic procedures.


  • Helps address the complete multi-phase glycation process known to visibly age skin
  • Visibly smooths fine lines and five wrinkle types, including forehead wrinkles, nasolabial folds, marionette wrinkles, glabellar wrinkles, and crow’s feet
  • Delivers 24-hour hydration in a rich, satin texture
  • Comforts dry, aging skin
  • Free of parabens, drying alcohol, and dyes

Collagen and elastin are responsible for skin’s youthful look. While many factors contribute to signs of aging in the skin, glycation of these structural proteins plays a significant role.

Glycation is a natural, multi-phase process that occurs when excess sugar molecules bind to proteins, including collagen and elastin, and form damaging byproducts known as advanced glycation end-products (A.G.E.s). External aggressors – such as UV, pollution, and diet – accelerate the glycation process, transforming collagen and elastin into A.G.E.s.

A.G.E.s turn flexible proteins rigid and brittle, making newly glycated collagen lose its critical regenerative ability. Once formed, these damaged proteins cannot be repaired or replaced, which ultimately weakens skin integrity and results in visible signs of ageing including wrinkles, crepiness, sagging, and dullness.

A.G.E. Interrupter Advanced is a potent corrective cream designed to help reverse accelerated signs of aging impacted by glycation and collagen decline. Formulated with a high-concentration combination of ProxylaneTM, wild fruit flavonoids, and glycyrrhetinic acid, this breakthrough anti-wrinkle cream helps correct visible skin aging and defend against new and recurring damage. All in a luxuriously textured formula.

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