Free Delivery Over €100

Fast 1-3 days, Ireland only

Book At Wellness Day Spa

Click here to book

Book At Woulfe Skin Specialists

Click here to book

Dublin's Top Aesthetic Skin Clinic & Day Spa

chevron_left chevron_right

SPMs – Specialised Pro-Resolving Mediators

SPMs – Specialised Pro-Resolving Mediators

What They Are

SPMs (Specialised Pro-Resolving Mediators) are bioactive molecules made from omega-3 fatty acids — mainly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

Unlike traditional anti-inflammatories that block inflammation, SPMs don’t suppress the immune response; they resolve it once healing should begin.

They’re the body’s natural “off switch” for inflammation.

How They Work

When tissue is injured or stressed, the body releases pro-inflammatory signals (IL-1β, IL-6, TNF-α) to fight infection and begin repair. Normally, once the job is done, SPMs are produced to:

  • Stop further recruitment of white blood cells

  • Clear cellular debris

  • Signal tissue regeneration

  • Return the tissue to a balanced state

If the body doesn’t produce enough SPMs — because of low omega-3 intake, chronic stress, poor sleep or metabolic imbalance — inflammation stays switched on.

That’s what underlies many modern conditions: acne flares, joint pain, autoimmunity, slow healing, and accelerated skin ageing.

The Science

Discovered in the early 2000s by Dr Charles Serhan at Harvard Medical School, SPMs include several families:

  • Resolvins (from EPA and DHA)

  • Protectins (from DHA)

  • Maresins (from macrophage enzymes acting on DHA)

Research in Nature Immunology and The Journal of Lipid Research shows that adequate omega-3 levels allow immune cells to make these compounds efficiently.

SPMs actively restore tissue homeostasis without compromising defence against infection — a key difference from long-term use of NSAIDs, which blunt both protection and healing.

Impact on Skin and Systemic Health

  • Calms chronic inflammation that drives acne, rosacea and psoriasis.

  • Supports wound healing and barrier repair after procedures.

  • Improves resilience against oxidative stress by reducing cytokine excess.

  • Balances immune response in both gut and skin microbiomes.

How to Support SPM Production

  • Diet: regular oily fish (salmon, mackerel, sardines), chia, flax, walnuts, or algae-based DHA/EPA supplements.

  • Lifestyle: adequate sleep, stress regulation and balanced blood sugar improve enzymatic conversion of omega-3s into SPMs.

  • Clinical context: chronic stress, poor diet, and low omega-3 status are the main reasons people underproduce them.

In essence:

Inflammation begins on purpose — but it’s meant to end on purpose, too.

SPMs are the molecules that close the loop, allowing healing without harm.

 

November 04, 2025

Leave a comment

Please note, comments need to be approved before they are published.